I am a postdoctoral researcher working with Cole Trapnell and Jay Shendure at University of Washington. Before that I received my Ph.D. from Stanford University, where I studied complex traits in the lab of Jonathan Pritchard. With my free time I like to dabble with watercolor painting, jog, and go hiking.
I enjoy thinking about how DNA is translated into life. Specifically, I am interested in understanding gene regulation and the development of complex traits.
A multiplex, prime editing framework for identifying drug resistance variants at scale. Florence M. Chardon, Chase C. Suiter, Riza M. Daza, Nahum T. Smith, Phoebe Parrish, Troy A. McDiarmid, Jean-Benoît Lalanne, Beth Martin, Diego Calderon, Amira Ellison, Alice H. Berger, Jay Shendure, Lea M. Starita. BioRxiv. [bioRiv][pdf]
Chromatin context-dependent regulation and epigenetic manipulation of prime editing. Li, Xiaoyi, Wei Chen, Beth K Martin, Diego Calderon, Choli Lee, Junhong Choi, Florence M. Chardon, Troy A. McDiarmid, Haedong Kim, Jean-Benoît Lalanne, Jenny F. Nathans, Jay Shendure. BioRxiv. [bioRiv][pdf]
Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements. Chardon, Florence M.*, Troy A. McDiarmid*, Nicholas F. Page, Beth K. Martin, Silvia Domcke, Samuel G. Regalado, Jean-Benoît Lalanne, Diego Calderon, Lea M. Starita, Stephan J. Sanders, Nadav Ahituv, Jay Shendure. BioRxiv. [bioRiv][pdf]
Multiplex profiling of developmental enhancers with quantitative, single-cell expression reporters. Lalanne, Jean-Benoît*, Samuel G. Regalado*, Silvia Domcke, Diego Calderon, Beth Martin, Tony Li, Chase C. Suiter, Choli Lee, Cole Trapnell, Jay Shendure. BioRxiv. [bioRxiv][pdf]
The continuum of Drosophila embryonic development at single-cell resolution. Diego Calderon*, Ronnie Blecher-Gonen*, Xingfan Huang*, Stefano Secchia*, James Kentro, Riza M. Daza, Beth Martin, Alessandro Dulja, Christoph Schaub, Cole Trapnell, Erica Larschan, Kate M. O’Connor-Giles, Eileen E. M. Furlong, Jay Shendure. Published in Science. [NCBI][Journal Site][pdf]
Systematic reconstruction of cellular trajectories across mouse embryogenesis. Qiu, Chengxiang, Junyue Cao, Beth K. Martin, Tony Li, Ian Walsh, Sanjay Srivatsan, Xingfan Huang, Diego Calderon, William Stafford Noble, Christine M. Disteche, Stephen A. Murray, Malte Spielmann, Cecilia B. Moens, Cole Trapnell, Jay Shendure. Published in Nature Genetics. [NCBI][Journal Site][pdf]
TransMPRA: A framework for assaying the role of many trans-acting factors at many enhancers. Calderon, Diego, Andria Ellis, Riza M. Daza, Beth Martin, Jacob M. Tome, Wei Chen, Florence M. Chardon, Anh Leith, Choli Lee, Cole Trapnell, Jay Shendure. BioRxiv. [bioRxiv][pdf]
Ancient Rome: A genetic crossroads of Europe and the Mediterranean. Antonio ML*, Gao Z*, Moots HM*, Lucci M, Candilio F, Sawyer S, Oberreiter V, Calderon D, Devitofranceschi K, Aikens RC, Aneli S, et al. Published in Science. [NCBI][Journal site]
Landscape of stimulation-responsive chromatin across diverse human immune cells. Calderon, Diego*, Michelle L.T. Nguyen*, Anja Mezger*, Arwa Kathiria, Fabian Müller, Vinh Nguyen, Ninnia Lescano, Beijing Wu, John Trombetta, Jessica V. Ribado, David A. Knowles, Ziyue Gao, Franziska Blaeschke, Audrey V. Parent, Trevor D. Burt, Mark S. Anderson, Lindsey A. Criswell, William J. Greenleaf, Alexander Marson, Jonathan K. Pritchard. Published in Nature Genetics. [NCBI][Journal site][pdf]
Impact of regulatory variation across human iPSCs and differentiated cells. Banovich, Nicholas E.*, Yang I. Li*, Anil Raj*, Michelle C. Ward, Peyton Greenside, Diego Calderon, Po Yuan Tung et al. Published in Genome Research. [NCBI][Journal site]
Inferring Relevant Cell Types for Complex Traits by Using Single-Cell Gene Expression. Calderon, Diego, Anand Bhaskar, David A. Knowles, David Golan, Towfique Raj, Audrey Q. Fu, and Jonathan K. Pritchard. Published in American Journal of Human Genetics. [NCBI][Journal site][pdf][software: CRAN][software: github repository]
The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system. Vonk, Freek J., Nicholas R. Casewell, Christiaan V. Henkel, Alysha M. Heimberg, Hans J. Jansen, Ryan JR McCleary, Harald ME Kerkkamp, et al. Published in Proceedings of the National Academy of Sciences. [NCBI][Journal site]
* Indicates co-authorship.